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HomoloGene:21267. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TLN1,  H.sapiens
talin 1
NP_006280.3
2541 aa
TLN1,  P.troglodytes
talin 1
XP_003312119.1
2548 aa
TLN1,  M.mulatta
talin 1
XP_001084941.2
2428 aa
TLN1,  C.lupus
talin 1
XP_005626844.1
2558 aa
TLN1,  B.taurus
talin 1
NP_001192357.1
2541 aa
Tln1,  M.musculus
talin 1
NP_035732.2
2541 aa
Tln1,  R.norvegicus
talin 1
NP_001034114.2
2541 aa
TLN1,  G.gallus
talin 1
NP_989854.1
2541 aa
tln1,  D.rerio
talin 1
NP_001009560.1
2538 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Functional and structural characterization of the talin F0F1 domain.
Domadia PN, et al. Biochem Biophys Res Commun 391, 159-65 (2010).
The structure of an interdomain complex that regulates talin activity.
Goult BT, et al. J Biol Chem 284, 15097-106 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Talin_middle (pfam09141)
  Talin, middle domain.
VBS (pfam08913)
  Vinculin Binding Site.
talin-RS (cd12150)
  rod-segment of the talin C-terminal domain.
FERM_M (pfam00373)
  FERM central domain.
FERM_N (pfam09379)
  FERM N-terminal domain.
Mtu_fam_mce (TIGR00996)
  virulence factor Mce family protein.
FERM_M (pfam00373)
  FERM central domain.
VBS (pfam08913)
  Vinculin Binding Site.
FERM_N (pfam09379)
  FERM N-terminal domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.
I_LWEQ (cl19756)
  I/LWEQ domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tln1 includes H.sapiens TLN1 and R.norvegicus Tln1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (16 transcripts, 9 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (4 transcripts, 2 species)
Insecta - insects (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

 

 

 

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