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HomoloGene:69152. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

OPN4,  H.sapiens
opsin 4
489 aa
OPN4,  P.troglodytes
opsin 4
489 aa
OPN4,  M.mulatta
opsin 4
434 aa
OPN4,  C.lupus
opsin 4
480 aa
OPN4,  B.taurus
opsin 4
478 aa
Opn4,  M.musculus
opsin 4 (melanopsin)
466 aa
Opn4,  R.norvegicus
opsin 4
474 aa
OPN4,  G.gallus
opsin 4
528 aa
LOC100491785,  X.tropicalis
592 aa
ninaE,  D.melanogaster
neither inactivation nor afterpotential E
373 aa
Rh2,  D.melanogaster
Rhodopsin 2
381 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

ninaE+ encodes the opsin moiety of the major rhodopsin, RH1, which occupies the rhabdomeres of the outer six photoreceptor cells R1-R6 in each ommatidium of the adult fly. This rhodopsin is also expressed in the larval light sensitive organs (Zucker, Cowman and Rubin, 1985; Pollack and Benzer, 1988). RH1 is a 39kD basic protein (Nichols and Pak, 1985). Homozygous ninaE mutants display severe depletion of rhodopsin from the outer photoreceptors, shown microspectrophotometrically and physiologically (Scavarda, O'Tousa and Pak, 1983; Johnson and Pak, 1986), as well as by absence of R1-6 staining with an anti-(Drosophila)rhodopsin MAb (de Couet and Tanimura, 1987). (See FlyBase for complete description.)
Encodes the opsin moiety of the rhodopsin specific to the ocelli. Not expressed in the eye nor is it expressed in Bolwig's organ, the larval photoreceptor (Pollock and Benzer, 1988). Rh2 under the control of the ninaE promoter in a ninaE background functions in R1-6 cells (Zuker, Mismer, Hardy, and Rubin, 1988) but with different spectral characteristics and physiology (Feiler, Harris, Kirschfield, Wehrkan and Zuker, 1988). RH2 is a 381-amino-acid protein that is 67% homologous to the opsin found in R1-6 encoded by ninaE, but only 35% homologous to RH3 and RH4..

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Opn4 includes H.sapiens OPN4 and R.norvegicus Opn4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Insecta - insects (20 transcripts, 8 species)
Malacostraca - crustaceans (3 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mammalia - mammals (5 transcripts, 5 species)
Actinopterygii - bony fishes (4 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)

Turbellaria - flatworms (1 transcript, 1 species)




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