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HomoloGene:11481. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

MFN1,  H.sapiens
mitofusin 1
741 aa
MFN1,  P.troglodytes
mitofusin 1
741 aa
MFN1,  M.mulatta
mitofusin 1
741 aa
MFN1,  C.lupus
mitofusin 1
742 aa
MFN1,  B.taurus
mitofusin 1
742 aa
Mfn1,  M.musculus
mitofusin 1
741 aa
Mfn1,  R.norvegicus
mitofusin 1
741 aa
MFN1,  G.gallus
mitofusin 1
740 aa
mfn1,  X.tropicalis
mitofusin 1
738 aa
mfn1b,  D.rerio
mitofusin 1b
740 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.
Fu M, et al. Mol Biol Cell 24, 1153-62 (2013).
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
Papanicolaou KN, et al. Circ Res 111, 1012-26 (2012).
Loss of mitofusin 2 promotes endoplasmic reticulum stress.
Ngoh GA, et al. J Biol Chem 287, 20321-32 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Fzo_mitofusin (pfam04799)
  fzo-like conserved region.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
RecA-like_NTPases (cl17233)
  RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mfn1 includes H.sapiens MFN1 and R.norvegicus Mfn1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (18 transcripts, 12 species)
Actinopterygii - bony fishes (15 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)




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