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HomoloGene:20927. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DVL2,  H.sapiens
dishevelled segment polarity protein 2
NP_004413.1
736 aa
DVL2,  P.troglodytes
dishevelled, dsh homolog 2 (Drosophila)
XP_003315389.1
736 aa
DVL2,  M.mulatta
dishevelled, dsh homolog 2 (Drosophila)
XP_001106375.1
736 aa
DVL2,  C.lupus
dishevelled segment polarity protein 2
XP_546582.2
736 aa
DVL2,  B.taurus
dishevelled, dsh homolog 2 (Drosophila)
NP_001178311.1
740 aa
Dvl2,  M.musculus
dishevelled 2, dsh homolog (Drosophila)
NP_031914.3
736 aa
Dvl2,  R.norvegicus
dishevelled 2
NP_001165527.1
736 aa
dvl2,  X.tropicalis
dishevelled segment polarity protein 2
NP_001072660.1
732 aa
dvl2,  D.rerio
dishevelled, dsh homolog 2 (Drosophila)
NP_997813.1
747 aa
dsh-1,  C.elegans
dsh-1
NP_494978.4
702 aa
dsh-2,  C.elegans
dsh-2
NP_494937.3
691 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

PDZ domain from Dishevelled -- a specificity study.
Śmietana K, et al. Acta Biochim Pol 58, 243-9 (2011).
The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization.
Schwarz-Romond T, et al. Nat Struct Mol Biol 14, 484-92 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Dishevelled (pfam02377)
  Dishevelled specific domain.
Dsh_C (pfam12316)
  Segment polarity protein dishevelled (Dsh) C terminal.
Dsh_C (pfam12316)
  Segment polarity protein dishevelled (Dsh) C terminal.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
DIX (cl02426)
  DIX domain.
DEP (cl02442)
  DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dvl2 includes H.sapiens DVL2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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