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HomoloGene:13242. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PSIP1,  H.sapiens
PC4 and SFRS1 interacting protein 1
530 aa
PSIP1,  C.lupus
PC4 and SFRS1 interacting protein 1
530 aa
PSIP1,  B.taurus
PC4 and SFRS1 interacting protein 1
530 aa
Psip1,  M.musculus
PC4 and SFRS1 interacting protein 1
528 aa
Psip1,  R.norvegicus
PC4 and SFRS1 interacting protein 1
528 aa
PSIP1,  G.gallus
PC4 and SFRS1 interacting protein 1
579 aa
psip1,  X.tropicalis
PC4 and SFRS1 interacting protein 1
565 aa
psip1,  D.rerio
PC4 and SFRS1 interacting protein 1
413 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

LEDGF (p75) promotes DNA-end resection and homologous recombination.
Daugaard M, et al. Nat Struct Mol Biol 19, 803-10 (2012).
LEDGF/p75 TATA-less promoter is driven by the transcription factor Sp1.
Desfarges S, et al. J Mol Biol 414, 177-93 (2011).
LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT.
Takeichi T, et al. J Dermatol Sci 63, 203-5 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LEDGF (pfam11467)
  Lens epithelium-derived growth factor (LEDGF).
PWWP (cl02554)
  The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Psip1 includes H.sapiens PSIP1 and R.norvegicus Psip1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (20 transcripts, 15 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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