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HomoloGene:21040. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MMP14,  H.sapiens
matrix metallopeptidase 14 (membrane-inserted)
NP_004986.1
582 aa
MMP14,  P.troglodytes
matrix metallopeptidase 14 (membrane-inserted)
XP_001157686.1
582 aa
MMP14,  M.mulatta
matrix metallopeptidase 14 (membrane-inserted)
XP_001100232.1
582 aa
MMP14,  C.lupus
matrix metallopeptidase 14 (membrane-inserted)
XP_856947.1
582 aa
MMP14,  B.taurus
matrix metallopeptidase 14 (membrane-inserted)
NP_776815.1
582 aa
Mmp14,  M.musculus
matrix metallopeptidase 14 (membrane-inserted)
NP_032634.3
582 aa
Mmp14,  R.norvegicus
matrix metallopeptidase 14 (membrane-inserted)
NP_112318.1
582 aa
mmp14,  X.tropicalis
matrix metallopeptidase 14 (membrane-inserted)
NP_001025559.1
578 aa
mmp14a,  D.rerio
matrix metalloproteinase 14a (membrane-inserted)
NP_919397.1
574 aa
mmp14b,  D.rerio
matrix metalloproteinase 14b (membrane-inserted)
NP_919395.1
621 aa
Mmp1,  D.melanogaster
Matrix metalloproteinase 1
NP_726473.2
584 aa
AgaP_AGAP006904,  A.gambiae
AgaP_AGAP006904
XP_001688107.1
570 aa
H36L18.1,  C.elegans
H36L18.1
NP_510112.2
420 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

MT1-MMP prevents growth inhibition by three dimensional fibronectin matrix.
Takino T, et al. Biochem Biophys Res Commun 436, 503-8 (2013).
The tetraspanin network modulates MT1-MMP cell surface trafficking.
Schröder HM, et al. Int J Biochem Cell Biol 45, 1133-44 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
DUF3377 (pfam11857)
  Domain of unknown function (DUF3377).
HX (cd00094)
  Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
DUF3377 (pfam11857)
  Domain of unknown function (DUF3377).
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mmp14 includes H.sapiens MMP14 and R.norvegicus Mmp14.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (6 transcripts, 2 species)
Cephalochordata - lancelets (5 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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