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HomoloGene:37735. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SPR,  H.sapiens
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
NP_003115.1
261 aa
SPR,  P.troglodytes
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
XP_525784.2
261 aa
SPR,  M.mulatta
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
XP_001103332.1
261 aa
SPR,  C.lupus
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
XP_540234.2
267 aa
SPR,  B.taurus
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
NP_001069471.1
267 aa
Spr,  M.musculus
sepiapterin reductase
NP_035597.2
262 aa
Spr,  R.norvegicus
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
NP_062054.1
262 aa
SPR,  G.gallus
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
XP_423038.1
268 aa
spr,  X.tropicalis
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
NP_001120067.1
261 aa
spra,  D.rerio
sepiapterin reductase a
NP_001019601.2
261 aa
sprb,  D.rerio
sepiapterin reductase b
NP_001122262.1
272 aa
Sptr,  D.melanogaster
Sepiapterin reductase
NP_727265.1
261 aa
AgaP_AGAP008000,  A.gambiae
AgaP_AGAP008000
XP_317468.3
288 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Sepiapterin reductase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Mutagenesis by imprecise excision of the piggyBac transposon in Drosophila melanogaster.
Kim H, et al. Biochem Biophys Res Commun 417, 335-9 (2012).
Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease.
Sharma M, et al. Neurobiol Aging 32, 2108.e1-5 (2011).
Two Greek siblings with sepiapterin reductase deficiency.
Verbeek MM, et al. Mol Genet Metab 94, 403-9 (2008).
A murine model for human sepiapterin-reductase deficiency.
Yang S, et al. Am J Hum Genet 78, 575-87 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NADB_Rossmann (cl09931)
  Rossmann-fold NAD(P)(+)-binding proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Spr includes H.sapiens SPR and R.norvegicus Spr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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