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HomoloGene:20584. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PITX1,  H.sapiens
paired-like homeodomain 1
NP_002644.4
314 aa
PITX1,  P.troglodytes
paired-like homeodomain 1
XP_001168135.1
314 aa
PITX1,  M.mulatta
paired-like homeodomain 1
XP_002804564.1
314 aa
PITX1,  C.lupus
paired-like homeodomain 1
XP_005626613.1
313 aa
PITX1,  B.taurus
paired-like homeodomain 1
NP_001192229.1
314 aa
Pitx1,  M.musculus
paired-like homeodomain transcription factor 1
NP_035227.1
315 aa
Pitx1,  R.norvegicus
paired-like homeodomain 1
NP_446076.1
315 aa
PITX1,  G.gallus
paired-like homeodomain 1
NP_001161158.1
302 aa
pitx1,  X.tropicalis
paired-like homeodomain 1
NP_001007500.1
305 aa
pitx1,  D.rerio
paired-like homeodomain transcription factor 1
NP_001035436.3
285 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Liebenberg syndrome: case report and insight into molecular basis.
Abdel-Ghani H, et al. J Hand Surg Am 38, 459-65 (2013).
New emerging role of pitx1 transcription factor in osteoarthritis pathogenesis.
Picard C, et al. Clin Orthop Relat Res 462, 59-66 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OAR (pfam03826)
  OAR domain.
OAR (pfam03826)
  OAR domain.
Fork_head_N (pfam08430)
  Forkhead N-terminal region.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pitx1 includes H.sapiens PITX1 and R.norvegicus Pitx1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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