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HomoloGene:36025. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

THRB,  H.sapiens
thyroid hormone receptor, beta
NP_001239563.1
461 aa
THRB,  P.troglodytes
thyroid hormone receptor, beta
XP_001163850.1
461 aa
THRB,  M.mulatta
thyroid hormone receptor, beta
XP_001090554.1
461 aa
THRB,  C.lupus
thyroid hormone receptor, beta
XP_862690.2
461 aa
THRB,  B.taurus
thyroid hormone receptor, beta
XP_005226243.1
459 aa
Thrb,  M.musculus
thyroid hormone receptor beta
NP_001106888.1
461 aa
Thrb,  R.norvegicus
thyroid hormone receptor beta
NP_001257783.1
461 aa
THRB,  G.gallus
thyroid hormone receptor, beta
NP_001239150.1
476 aa
thrb,  X.tropicalis
thyroid hormone receptor beta
NP_001039270.1
383 aa
thrb,  D.rerio
thyroid hormone receptor beta
NP_571415.1
386 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Thyroid hormone resistance.
Thyroid hormone resistance, autosomal recessive.



Publications
Articles associated with genes and sequences of this homology group.

Thyroid hormone resistance caused by a novel deleterious variant of the thyroid hormone receptor beta gene.
Beato-Víbora P, et al. Eur J Obstet Gynecol Reprod Biol 167, 118-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Thrb includes H.sapiens THRB and R.norvegicus Thrb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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