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HomoloGene:128512. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MYH11,  H.sapiens
myosin, heavy chain 11, smooth muscle
NP_001035203.1
1979 aa
LOC453949,  P.troglodytes
myosin-11-like
XP_003952852.1
1841 aa
MYH11,  M.mulatta
myosin, heavy chain 11, smooth muscle
XP_001109463.2
1963 aa
MYH11,  C.lupus
myosin, heavy chain 11, smooth muscle
XP_005621571.1
1979 aa
MYH11,  B.taurus
myosin, heavy chain 11, smooth muscle
NP_001095597.1
1972 aa
Myh11,  M.musculus
myosin, heavy polypeptide 11, smooth muscle
NP_001155247.1
1972 aa
Myh11,  R.norvegicus
myosin, heavy chain 11, smooth muscle
NP_001164071.1
1972 aa
MYH11,  G.gallus
myosin, heavy chain 11, smooth muscle
NP_990605.1
1979 aa
LOC100490639,  X.tropicalis
myosin-11-like
XP_002932251.1
1980 aa
myh11a,  D.rerio
myosin, heavy polypeptide 11, smooth muscle a
NP_001019619.1
1974 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Aortic aneurysm, familial thoracic 4.



Publications
Articles associated with genes and sequences of this homology group.

Mutation analysis of MYH11 in acute myeloid leukemia.
Sammalkorpi H, et al. Leuk Lymphoma 49, 1829-31 (2008).
Somatic mutation analysis of MYH11 in breast and prostate cancer.
Alhopuro P, et al. BMC Cancer 8, 263 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
phage_LysB (TIGR03495)
  phage lysis regulatory protein, LysB family.
Orbi_VP5 (pfam00901)
  Orbivirus outer capsid protein VP5.
Phage_lysis (pfam03245)
  Bacteriophage lysis protein.
TMF_TATA_bd (pfam12325)
  TATA element modulatory factor 1 TATA binding.
COG1340 (COG1340)
  Uncharacterized archaeal coiled-coil protein [Function unknown].
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
GvpL_GvpF (pfam06386)
  Gas vesicle synthesis protein GvpL/GvpF.
TMF_TATA_bd (pfam12325)
  TATA element modulatory factor 1 TATA binding.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myh11 includes H.sapiens MYH11 and R.norvegicus Myh11.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (20 transcripts, 10 species)
Mammalia - mammals (19 transcripts, 14 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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