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HomoloGene:74514. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

IQGAP1,  H.sapiens
IQ motif containing GTPase activating protein 1
1657 aa
IQGAP1,  P.troglodytes
IQ motif containing GTPase activating protein 1
1657 aa
IQGAP1,  M.mulatta
IQ motif containing GTPase activating protein 1
1703 aa
IQGAP1,  C.lupus
IQ motif containing GTPase activating protein 1
1657 aa
Iqgap1,  M.musculus
IQ motif containing GTPase activating protein 1
1657 aa
Iqgap1,  R.norvegicus
IQ motif containing GTPase activating protein 1
1657 aa
IQGAP1,  G.gallus
IQ motif containing GTPase activating protein 1
1658 aa
iqgap1,  X.tropicalis
IQ motif containing GTPase activating protein 1
1657 aa
iqgap1,  D.rerio
IQ motif containing GTPase activating protein 1
1533 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IQ (pfam00612)
  IQ calmodulin-binding motif.
IQ (cl15479)
  IQ calmodulin-binding motif.
RasGAP_C (pfam03836)
  RasGAP C-terminus.
RasGAP (cl02569)
  Ras GTPase Activating Domain.
RasGAP_C (pfam03836)
  RasGAP C-terminus.
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
RasGAP (cl02569)
  Ras GTPase Activating Domain.
IQ (cl15479)
  Calmodulin-binding motif.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Iqgap1 includes H.sapiens IQGAP1 and R.norvegicus Iqgap1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (29 transcripts, 11 species)
Mammalia - mammals (25 transcripts, 14 species)
Aves - birds (6 transcripts, 2 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Insecta - insects (2 transcripts, 2 species)

Gastropoda - gastropods (2 transcripts, 1 species)

Echinoidea - sea urchins (2 transcripts, 2 species)




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