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HomoloGene:94. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

EPHX1,  H.sapiens
epoxide hydrolase 1, microsomal (xenobiotic)
NP_000111.1
455 aa
EPHX1,  P.troglodytes
epoxide hydrolase 1, microsomal (xenobiotic)
XP_003308837.2
534 aa
EPHX1,  M.mulatta
epoxide hydrolase 1, microsomal (xenobiotic)
XP_001093424.1
455 aa
EPHX1,  C.lupus
epoxide hydrolase 1, microsomal (xenobiotic)
XP_863972.2
454 aa
EPHX1,  B.taurus
epoxide hydrolase 1, microsomal (xenobiotic)
NP_001029801.1
451 aa
Ephx1,  M.musculus
epoxide hydrolase 1, microsomal
NP_034275.1
455 aa
Ephx1,  R.norvegicus
epoxide hydrolase 1, microsomal (xenobiotic)
NP_001029262.1
455 aa
EPHX1,  G.gallus
epoxide hydrolase 1, microsomal (xenobiotic)
XP_419386.2
464 aa
ephx1,  X.tropicalis
epoxide hydrolase 1, microsomal (xenobiotic)
NP_001121449.1
457 aa
ephx1,  D.rerio
epoxide hydrolase 1, microsomal (xenobiotic)
NP_957362.1
456 aa
Jheh2,  D.melanogaster
Juvenile hormone epoxide hydrolase 2
NP_611386.2
463 aa
AgaP_AGAP008684,  A.gambiae
AgaP_AGAP008684
XP_314783.2
458 aa
AgaP_AGAP008686,  A.gambiae
AgaP_AGAP008686
XP_557830.2
462 aa
W01A11.1,  C.elegans
W01A11.1
NP_504650.1
452 aa
MGG_14882,  M.oryzae
MGG_14882
XP_003716557.1
422 aa
NCU08783,  N.crassa
NCU08783
XP_956226.1
430 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Preeclampsia, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

EPHX1 A139G polymorphism and lung cancer risk: a meta-analysis.
Liu H, et al. Tumour Biol 34, 155-63 (2013).
DNA damage and susceptibility assessment in industrial workers exposed to styrene.
Costa C, et al. J Toxicol Environ Health A 75, 735-46 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
EHN (pfam06441)
  Epoxide hydrolase N terminus.
Abhydrolase_6 (pfam12697)
  Alpha/beta hydrolase family.
MhpC (COG0596)
  Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
EHN (pfam06441)
  Epoxide hydrolase N terminus.
Hydrolase_4 (cl19140)
  Putative lysophospholipase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ephx1 includes H.sapiens EPHX1 and R.norvegicus Ephx1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 16 species)
Actinopterygii - bony fishes (13 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Platyhelminthes
Turbellaria - flatworms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 2 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

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