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HomoloGene:31056. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CHN1,  H.sapiens
chimerin 1
NP_001813.1
459 aa
CHN1,  M.mulatta
chimerin 1
XP_001093000.2
833 aa
CHN1,  B.taurus
chimerin (chimaerin) 1
NP_001106718.1
459 aa
Chn1,  M.musculus
chimerin 1
NP_001106717.2
459 aa
Chn3,  R.norvegicus
chimerin 3
XP_002728615.3
495 aa
CHN1,  G.gallus
chimerin (chimaerin) 1
NP_001012970.1
459 aa
chn1,  D.rerio
chimerin (chimaerin) 1
NP_998165.1
459 aa
RhoGAP5A,  D.melanogaster
RhoGAP5A
NP_727007.1
494 aa
AgaP_AGAP003026,  A.gambiae
AgaP_AGAP003026
XP_311850.4
465 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Duane retraction syndrome 2.



Publications
Articles associated with genes and sequences of this homology group.

Expansion of the CHN1 strabismus phenotype.
Miyake N, et al. Invest Ophthalmol Vis Sci 52, 6321-8 (2011).
Two novel CHN1 mutations in 2 families with Duane retraction syndrome.
Chan WM, et al. Arch Ophthalmol 129, 649-52 (2011).
Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders.
Volk AE, et al. Graefes Arch Clin Exp Ophthalmol 248, 1351-7 (2010).
Duane Syndrome
Andrews CV, et al. (1993).
CHN1 mutations are not a common cause of sporadic Duane's retraction syndrome.
Miyake N, et al. Am J Med Genet A 152A, 215-7 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
SH2 (cl15255)
  Src homology 2 (SH2) domain.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
B_zip1 (cl02576)
  basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins.
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chn1 includes H.sapiens CHN1 and R.norvegicus Chn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (21 transcripts, 8 species)
Mammalia - mammals (18 transcripts, 12 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Amphibia - amphibians (4 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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