Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:56546. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CLCN7,  H.sapiens
chloride channel, voltage-sensitive 7
NP_001278.1
805 aa
CLCN7,  P.troglodytes
chloride channel, voltage-sensitive 7
XP_001159424.1
805 aa
CLCN7,  M.mulatta
chloride channel, voltage-sensitive 7
XP_002802404.1
782 aa
CLCN7,  C.lupus
chloride channel, voltage-sensitive 7
XP_537014.2
809 aa
CLCN7,  B.taurus
chloride channel 7
NP_001020502.1
809 aa
Clcn7,  M.musculus
chloride channel 7
NP_036060.1
803 aa
Clcn7,  R.norvegicus
chloride channel, voltage-sensitive 7
NP_113756.1
803 aa
CLCN7,  G.gallus
chloride channel, voltage-sensitive 7
NP_001025815.1
802 aa
clcn7,  X.tropicalis
chloride channel, voltage-sensitive 7
NP_001041533.1
797 aa
clcn7,  D.rerio
chloride channel 7
NP_001071005.1
795 aa
ClC-b,  D.melanogaster
Chloride channel-b
NP_610798.1
813 aa
AgaP_AGAP007499,  A.gambiae
AgaP_AGAP007499
XP_308378.4
759 aa
clh-6,  C.elegans
clh-6
NP_506022.1
796 aa
AT5G33280,  A.thaliana
AT5G33280
NP_198313.2
765 aa
CLC-C,  A.thaliana
CLC-C
NP_199800.1
779 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Osteopetrosis, autosomal dominant, type II.
Osteopetrosis, recessive.



Publications
Articles associated with genes and sequences of this homology group.

CLCN7-Related Osteopetrosis
Sobacchi C, et al. (1993).
Characterization of acid flux in osteoclasts from patients harboring a G215R mutation in ClC-7.
Henriksen K, et al. Biochem Biophys Res Commun 378, 804-9 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COG0517 (COG0517)
  FOG: CBS domain [General function prediction only].
Voltage_gated_ClC (cl02915)
  CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
Voltage_gated_ClC (cl02915)
  CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
CBS_pair (cl15354)
  The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Clcn7 includes H.sapiens CLCN7 and R.norvegicus Clcn7.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Arachnida - arachnids (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (16 transcripts, 12 species)
Liliopsida - monocots (11 transcripts, 6 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

Support Center