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HomoloGene:3603. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CLOCK,  H.sapiens
clock circadian regulator
846 aa
CLOCK,  P.troglodytes
clock homolog (mouse)
847 aa
LOC697532,  M.mulatta
circadian locomoter output cycles protein kaput-like
823 aa
CLOCK,  C.lupus
clock circadian regulator
847 aa
CLOCK,  B.taurus
clock homolog (mouse)
845 aa
Clock,  M.musculus
circadian locomotor output cycles kaput
855 aa
Clock,  R.norvegicus
clock circadian regulator
862 aa
CLOCK,  G.gallus
clock homolog (mouse)
875 aa
clock,  X.tropicalis
clock circadian regulator
829 aa
clock,  D.rerio
893 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice.
Dankel SN, et al. Am J Physiol Endocrinol Metab 306, E210-24 (2014).
hClock gene expression in human colorectal carcinoma.
Wang L, et al. Mol Med Rep 8, 1017-22 (2013).
Circadian clock regulates the host response to Salmonella.
Bellet MM, et al. Proc Natl Acad Sci U S A 110, 9897-902 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PAS (pfam00989)
  PAS fold.
PAS_3 (pfam08447)
  PAS fold.
PAS (cd00130)
  PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
PAS (pfam00989)
  PAS fold.
PAS_11 (pfam14598)
  PAS domain.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Clock includes H.sapiens CLOCK and R.norvegicus Clock.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (13 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 4 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Insecta - insects (8 transcripts, 8 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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