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HomoloGene:49498. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TET2,  H.sapiens
tet methylcytosine dioxygenase 2
NP_001120680.1
2002 aa
TET2,  P.troglodytes
tet methylcytosine dioxygenase 2
XP_526645.2
2023 aa
TET2,  M.mulatta
tet methylcytosine dioxygenase 2
XP_001082840.2
1973 aa
TET2,  C.lupus
tet methylcytosine dioxygenase 2
XP_535678.3
2018 aa
TET2,  B.taurus
tet methylcytosine dioxygenase 2
XP_005207739.1
2007 aa
Tet2,  M.musculus
tet methylcytosine dioxygenase 2
NP_001035490.2
1912 aa
Tet2,  R.norvegicus
tet methylcytosine dioxygenase 2
XP_006233409.1
1959 aa
TET2,  G.gallus
tet methylcytosine dioxygenase 2
NP_001264723.1
1955 aa
tet2,  X.tropicalis
tet methylcytosine dioxygenase 2
XP_002934823.2
1792 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma.
Jäwert F, et al. Anticancer Res 33, 4325-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tet_JBP (pfam12851)
  Oxygenase domain of the 2OGFeDO superfamily.
DUF1421 (pfam07223)
  Protein of unknown function (DUF1421).
Tet_JBP (pfam12851)
  Oxygenase domain of the 2OGFeDO superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tet2 includes H.sapiens TET2 and R.norvegicus RGD1311625.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Aves - birds (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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