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HomoloGene:69159. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CNTNAP2,  H.sapiens
contactin associated protein-like 2
NP_054860.1
1331 aa
CNTNAP2,  P.troglodytes
contactin associated protein-like 2
XP_519462.2
1331 aa
CNTNAP2,  M.mulatta
contactin associated protein-like 2
XP_001094652.1
1331 aa
CNTNAP2,  C.lupus
contactin associated protein-like 2
XP_003432128.1
1331 aa
CNTNAP2,  B.taurus
contactin associated protein-like 2
XP_002687183.2
1331 aa
Cntnap2,  M.musculus
contactin associated protein-like 2
NP_001004357.2
1332 aa
Cntnap2,  R.norvegicus
contactin associated protein-like 2
XP_006236462.1
638 aa
CNTNAP2,  G.gallus
contactin associated protein-like 2
XP_004935116.1
1328 aa
cntnap2,  X.tropicalis
contactin associated protein-like 2
NP_001072732.1
1323 aa
cntnap2a,  D.rerio
contactin associated protein-like 2a
XP_001919314.3
1316 aa
Nrx-IV,  D.melanogaster
Neurexin IV
NP_729787.2
1284 aa
AgaP_AGAP007545,  A.gambiae
AgaP_AGAP007545
XP_001687897.1
1242 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cortical dysplasia-focal epilepsy syndrome.



Publications
Articles associated with genes and sequences of this homology group.

CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study.
Clemm von Hohenberg C, et al. J Psychiatr Res 47, 1349-56 (2013).
What does CNTNAP2 reveal about autism spectrum disorder?
Pe├▒agarikano O & Geschwind DH. Trends Mol Med 18, 156-63 (2012).
Genetic variation in CNTNAP2 alters brain function during linguistic processing in healthy individuals.
Whalley HC, et al. Am J Med Genet B Neuropsychiatr Genet 156B, 941-8 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
4.1m (smart00294)
  putative band 4.1 homologues' binding motif.
COLFI (cl02436)
  Fibrillar collagen C-terminal domain.
COLFI (cl02436)
  Fibrillar collagen C-terminal domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
FA58C (cl19067)
  Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cntnap2 includes H.sapiens CNTNAP2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 9 species)
Actinopterygii - bony fishes (15 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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