Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:21084. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ERBB4,  H.sapiens
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
NP_005226.1
1308 aa
ERBB4,  P.troglodytes
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
XP_516067.2
1308 aa
ERBB4,  C.lupus
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
XP_003640239.1
1298 aa
ERBB4,  B.taurus
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
XP_002685604.3
1110 aa
Erbb4,  M.musculus
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
NP_034284.1
1292 aa
Erbb4,  R.norvegicus
v-erb-b2 avian erythroblastic leukemia viral oncogene 4
NP_067719.1
1308 aa
ERBB4,  G.gallus
v-erb-a erythroblastic leukemia viral oncogene homolog 4
NP_001025536.1
1276 aa
erbb4,  X.tropicalis
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
XP_004917906.1
1322 aa
erbb4a,  D.rerio
v-erb-a erythroblastic leukemia viral oncogene homolog 4a (avian)
NP_001137223.1
1414 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

ERBB4 confers metastatic capacity in Ewing sarcoma.
Mendoza-Naranjo A, et al. EMBO Mol Med 5, 1087-102 (2013).
Mutations in ERBB4 may have a minor role in melanoma pathogenesis.
Manca A, et al. J Invest Dermatol 133, 1685-7 (2013).
Proteolytic processing of ErbB4 in breast cancer.
Hollmén M, et al. PLoS One 7, e39413 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TM_EGFR-like (cl17045)
  Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases.
Recep_L_domain (pfam01030)
  Receptor L domain.
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Recep_L_domain (pfam01030)
  Receptor L domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Erbb4 includes H.sapiens ERBB4 and R.norvegicus Erbb4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

Support Center