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HomoloGene:56678. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

LATS2,  H.sapiens
large tumor suppressor kinase 2
1088 aa
LATS2,  P.troglodytes
LATS, large tumor suppressor, homolog 2 (Drosophila)
1088 aa
LATS2,  C.lupus
large tumor suppressor kinase 2
1085 aa
Lats2,  M.musculus
large tumor suppressor 2
1042 aa
Lats2,  R.norvegicus
large tumor suppressor 2
1042 aa
LATS2,  G.gallus
LATS, large tumor suppressor, homolog 2 (Drosophila)
1125 aa
lats2,  X.tropicalis
large tumor suppressor kinase 2
908 aa
lats2,  D.rerio
LATS, large tumor suppressor, homolog 2 (Drosophila)
1078 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

LATS2 is a tumor suppressor gene of malignant mesothelioma.
Murakami H, et al. Cancer Res 71, 873-83 (2011).
Lats2, a putative tumor suppressor, inhibits G1/S transition.
Li Y, et al. Oncogene 22, 4398-405 (2003).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Med25_SD1 (pfam11235)
  Mediator complex subunit 25 synapsin 1.
UBA (cl00153)
  Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lats2 includes H.sapiens LATS2 and R.norvegicus Lats2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 9 species)
Aves - birds (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)




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