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HomoloGene:84739. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SYNGAP1,  H.sapiens
synaptic Ras GTPase activating protein 1
NP_006763.2
1343 aa
SYNGAP1,  P.troglodytes
synaptic Ras GTPase activating protein 1
XP_003311264.1
1343 aa
SYNGAP1,  M.mulatta
synaptic Ras GTPase activating protein 1
XP_001109824.1
1284 aa
SYNGAP1,  C.lupus
synaptic Ras GTPase activating protein 1
XP_005627810.1
1190 aa
SYNGAP1,  B.taurus
synaptic Ras GTPase activating protein 1
NP_001192395.1
1346 aa
Syngap1,  M.musculus
synaptic Ras GTPase activating protein 1 homolog (rat)
NP_001268420.1
1340 aa
Syngap1,  R.norvegicus
synaptic Ras GTPase activating protein 1
NP_851606.3
1308 aa
syngap1,  X.tropicalis
synaptic Ras GTPase activating protein 1
NP_001128288.1
827 aa
LOC100151149,  D.rerio
ras GTPase-activating protein SynGAP-like
XP_001919204.4
1355 aa
si:dkeyp-24a7.8,  D.rerio
si:dkeyp-24a7.8
XP_005159373.1
1313 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Mental retardation, autosomal dominant 5.



Publications
Articles associated with genes and sequences of this homology group.

SynGAP isoforms exert opposing effects on synaptic strength.
McMahon AC, et al. Nat Commun 3, 900 (2012).
De novo autosomal dominant mutation in SYNGAP1.
Cook EH Jr. Autism Res 4, 155-6 (2011).
De novo SYNGAP1 mutations in nonsyndromic intellectual disability and autism.
Hamdan FF, et al. Biol Psychiatry 69, 898-901 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl00273)
  Pleckstrin homology-like domain.
DUF3498 (pfam12004)
  Domain of unknown function (DUF3498).
PH-like (cl17171)
  Pleckstrin homology-like domain.
Jnk-SapK_ap_N (pfam09744)
  JNK_SAPK-associated protein-1.
DUF3498 (pfam12004)
  Domain of unknown function (DUF3498).
RasGAP (cl02569)
  Ras GTPase Activating Domain.
C2 (cl14603)
  C2 domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Syngap1 includes H.sapiens SYNGAP1 and R.norvegicus Syngap1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 7 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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