Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:81827. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SIRT3,  H.sapiens
sirtuin 3
NP_036371.1
399 aa
SIRT3,  P.troglodytes
sirtuin 3
XP_003312891.1
327 aa
SIRT3,  M.mulatta
sirtuin 3
XP_001116486.2
375 aa
SIRT3,  C.lupus
sirtuin 3
XP_855809.1
372 aa
SIRT3,  B.taurus
sirtuin 3
NP_001193598.1
333 aa
Sirt3,  M.musculus
sirtuin 3
NP_001171275.1
334 aa
Sirt3,  R.norvegicus
sirtuin 3
NP_001099783.1
257 aa
SIRT3,  G.gallus
sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
NP_001186422.1
346 aa
sirt3,  X.tropicalis
sirtuin 3
XP_002937698.2
363 aa
sirt3,  D.rerio
sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
NP_001073643.1
357 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

SirT3 regulates the mitochondrial unfolded protein response.
Papa L & Germain D. Mol Cell Biol 34, 699-710 (2014).
Ethanol metabolism modifies hepatic protein acylation in mice.
Fritz KS, et al. PLoS One 8, e75868 (2013).
Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension.
Waypa GB, et al. Am J Respir Cell Mol Biol 49, 885-91 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SIR2 (cl00195)
  SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
SIR2 (cl00195)
  SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sirt3 includes H.sapiens SIRT3 and R.norvegicus Sirt3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

Support Center