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HomoloGene:4277. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ZMPSTE24,  H.sapiens
zinc metallopeptidase STE24
NP_005848.2
475 aa
ZMPSTE24,  P.troglodytes
zinc metallopeptidase STE24 homolog (S. cerevisiae)
XP_513352.2
475 aa
ZMPSTE24,  M.mulatta
zinc metallopeptidase STE24 homolog (S. cerevisiae)
XP_001082852.1
475 aa
ZMPSTE24,  C.lupus
zinc metallopeptidase STE24
XP_539577.3
473 aa
ZMPSTE24,  B.taurus
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
NP_001179857.1
475 aa
Zmpste24,  M.musculus
zinc metallopeptidase, STE24
NP_766288.1
475 aa
Zmpste24,  R.norvegicus
zinc metallopeptidase STE24
NP_001101444.1
475 aa
ZMPSTE24,  G.gallus
zinc metallopeptidase STE24
XP_417720.1
465 aa
zmpste24,  X.tropicalis
zinc metallopeptidase STE24
NP_001017255.1
466 aa
zmpste24,  D.rerio
zinc metallopeptidase, STE24 homolog
NP_956186.1
468 aa
ste24a,  D.melanogaster
prenyl protease type I
NP_611175.1
451 aa
AgaP_AGAP004470,  A.gambiae
AgaP_AGAP004470
XP_313769.4
454 aa
fce-1,  C.elegans
fce-1
NP_492582.1
442 aa
STE24,  S.cerevisiae
STE24
NP_012651.1
453 aa
KLLA0D10846g,  K.lactis
KLLA0D10846g
XP_453545.1
456 aa
SPAC3H1.05,  S.pombe
SPAC3H1.05
NP_593547.1
474 aa
MGG_06951,  M.oryzae
MGG_06951
XP_003709694.1
459 aa
NCU03637,  N.crassa
NCU03637
XP_961364.2
464 aa
ATSTE24,  A.thaliana
ATSTE24
NP_567212.1
424 aa
Os02g0680400,  O.sativa
Os02g0680400
NP_001047739.1
425 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Restrictive dermopathy, lethal.
Mandibuloacral dysplasia with type B lipodystrophy.



Publications
Articles associated with genes and sequences of this homology group.

The structural basis of ZMPSTE24-dependent laminopathies.
Quigley A, et al. Science 339, 1604-7 (2013).
Structure of the integral membrane protein CAAX protease Ste24p.
Pryor EE Jr, et al. Science 339, 1600-4 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_M48 (pfam01435)
  Peptidase family M48.
Peptidase_M48 (cl12018)
  Peptidase family M48.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Zmpste24 includes H.sapiens ZMPSTE24 and R.norvegicus Zmpste24.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 13 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (31 transcripts, 26 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (7 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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