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HomoloGene:20968. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TSPAN8,  H.sapiens
tetraspanin 8
NP_004607.1
237 aa
TSPAN8,  P.troglodytes
tetraspanin 8
XP_001157562.1
237 aa
TSPAN8,  M.mulatta
tetraspanin 8
XP_001117478.2
237 aa
TSPAN8,  C.lupus
tetraspanin 8
XP_531678.2
237 aa
TSPAN8,  B.taurus
tetraspanin 8
NP_001073097.1
238 aa
Tspan8,  M.musculus
tetraspanin 8
NP_666122.1
235 aa
Tspan8,  R.norvegicus
tetraspanin 8
NP_598210.1
235 aa
TSPAN8,  G.gallus
tetraspanin 8
NP_001186579.1
241 aa
tspan8,  X.tropicalis
tetraspanin 8
NP_001011430.2
230 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Reduced body weight in male Tspan8-deficient mice.
Champy MF, et al. Int J Obes (Lond) 35, 605-17 (2011).
Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia.
Scholz CJ, et al. Am J Med Genet B Neuropsychiatr Genet 153B, 967-72 (2010).
Overexpression of tetraspanin CO-029 in hepatocellular carcinoma.
Kanetaka K, et al. J Hepatol 35, 637-42 (2001).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
tetraspanin_LEL (cl02781)
  Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tspan8 includes H.sapiens TSPAN8 and R.norvegicus Tspan8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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