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HomoloGene:1936. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PAK1,  H.sapiens
p21 protein (Cdc42/Rac)-activated kinase 1
NP_002567.3
545 aa
PAK1,  P.troglodytes
p21 protein (Cdc42/Rac)-activated kinase 1
XP_508657.3
553 aa
PAK1,  M.mulatta
p21 protein (Cdc42/Rac)-activated kinase 1
XP_001090310.1
545 aa
PAK1,  C.lupus
p21 protein (Cdc42/Rac)-activated kinase 1
XP_849651.1
544 aa
PAK1,  B.taurus
p21 protein (Cdc42/Rac)-activated kinase 1
NP_001070366.1
544 aa
Pak1,  M.musculus
p21 protein (Cdc42/Rac)-activated kinase 1
NP_035165.2
544 aa
Pak1,  R.norvegicus
p21 protein (Cdc42/Rac)-activated kinase 1
NP_058894.1
544 aa
PAK1,  G.gallus
p21 protein (Cdc42/Rac)-activated kinase 1
NP_001155844.1
544 aa
pak1,  D.rerio
p21/Cdc42/Rac1-activated kinase 1
NP_958485.1
577 aa
Pak,  D.melanogaster
PAK-kinase
NP_001262313.1
704 aa
AgaP_AGAP002986,  A.gambiae
AgaP_AGAP002986
XP_311901.5
794 aa
pak-1,  C.elegans
pak-1
NP_001024378.1
569 aa
STE20,  S.cerevisiae
STE20
NP_011856.1
939 aa
shk1,  S.pombe
shk1
NP_596626.1
658 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

PAK1 mediates resistance to PI3K inhibition in lymphomas.
Walsh K, et al. Clin Cancer Res 19, 1106-15 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CRIB (cl00113)
  PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pak1 includes H.sapiens PAK1 and R.norvegicus Pak1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 13 species)
Actinopterygii - bony fishes (16 transcripts, 8 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 1 species)
Turbellaria - flatworms (4 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (4 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 2 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

 

 

 

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