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HomoloGene:10008. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MTPAP,  H.sapiens
mitochondrial poly(A) polymerase
NP_060579.3
582 aa
MTPAP,  P.troglodytes
mitochondrial poly(A) polymerase
XP_001136690.1
582 aa
MTPAP,  M.mulatta
mitochondrial poly(A) polymerase
XP_001083177.1
582 aa
MTPAP,  C.lupus
mitochondrial poly(A) polymerase
XP_535150.2
584 aa
MTPAP,  B.taurus
mitochondrial poly(A) polymerase
XP_002692192.2
583 aa
Mtpap,  M.musculus
mitochondrial poly(A) polymerase
NP_080433.1
585 aa
Mtpap,  R.norvegicus
mitochondrial poly(A) polymerase
NP_001100829.1
336 aa
MTPAP,  G.gallus
mitochondrial poly(A) polymerase
XP_418580.4
576 aa
mtpap,  X.tropicalis
mitochondrial poly(A) polymerase
XP_002940378.2
578 aa
LOC563801,  D.rerio
poly(A) RNA polymerase, mitochondrial-like
XP_692256.4
580 aa
CG11418,  D.melanogaster
CG11418
NP_001259129.1
612 aa
AgaP_AGAP003293,  A.gambiae
AgaP_AGAP003293
XP_319519.4
568 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ataxia, spastic, 4.



Publications
Articles associated with genes and sequences of this homology group.

Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.
Tomecki R, et al. Nucleic Acids Res 32, 6001-14 (2004).
Defective mitochondrial mRNA maturation is associated with spastic ataxia.
Crosby AH, et al. Am J Hum Genet 87, 655-60 (2010).
Gene regulation: reviving the message.
Keller W & Martin G. Nature 419, 267-8 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PAP_assoc (pfam03828)
  Cid1 family poly A polymerase.
PAP_assoc (pfam03828)
  Cid1 family poly A polymerase.
Rel-Spo_like (cl11966)
  RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain.
RRM_SF (cl17169)
  RNA recognition motif (RRM) superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mtpap includes H.sapiens MTPAP and R.norvegicus Papd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

 

 

 

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