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HomoloGene:38151. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ENPP1,  H.sapiens
ectonucleotide pyrophosphatase/phosphodiesterase 1
NP_006199.2
925 aa
ENPP1,  P.troglodytes
ectonucleotide pyrophosphatase/phosphodiesterase 1
XP_518743.3
925 aa
ENPP1,  M.mulatta
ectonucleotide pyrophosphatase/phosphodiesterase 1
XP_001103359.1
925 aa
ENPP1,  C.lupus
ectonucleotide pyrophosphatase/phosphodiesterase 1
XP_003638833.1
916 aa
ENPP1,  B.taurus
ectonucleotide pyrophosphatase/phosphodiesterase 1
NP_001193141.1
924 aa
Enpp1,  M.musculus
ectonucleotide pyrophosphatase/phosphodiesterase 1
NP_032839.3
905 aa
Enpp1,  R.norvegicus
ectonucleotide pyrophosphatase/phosphodiesterase 1
NP_445987.1
906 aa
ENPP1,  G.gallus
ectonucleotide pyrophosphatase/phosphodiesterase 1
XP_424539.4
912 aa
enpp1,  X.tropicalis
ectonucleotide pyrophosphatase/phosphodiesterase 1
XP_002936360.2
889 aa
enpp1,  D.rerio
ectonucleotide pyrophosphatase/phosphodiesterase 1
NP_001025339.1
876 aa
CELE_C27A7.3,  C.elegans
CELE_C27A7.3
NP_001041087.1
743 aa
CELE_C27A7.1,  C.elegans
CELE_C27A7.1
NP_001041086.1
824 aa
AT4G29680,  A.thaliana
AT4G29680
NP_194697.1
496 aa
Os01g0196600,  O.sativa
Os01g0196600
NP_001042295.1
479 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, non-insulin-dependent, susceptibility to.
Arterial calcification, generalized, of infancy.
Obesity, susceptibility to.
Ossification of posterior longitudinal ligament of spine.



Publications
Articles associated with genes and sequences of this homology group.

Cole Disease Results from Mutations in ENPP1.
Eytan O, et al. Am J Hum Genet 93, 752-7 (2013).
Adipose tissue dysfunction in humans: a potential role for the transmembrane protein ENPP1.
Chandalia M, et al. J Clin Endocrinol Metab 97, 4663-72 (2012).
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1.
Kato K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 68, 778-82 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Somatomedin_B (pfam01033)
  Somatomedin B domain.
Phosphodiest (pfam01663)
  Type I phosphodiesterase / nucleotide pyrophosphatase.
NUC (cl00089)
  DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
Somatomedin_B (cl02508)
  Somatomedin B domain.
Sulfatase (cl19157)
  Sulfatase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Enpp1 includes H.sapiens ENPP1 and R.norvegicus Enpp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (44 transcripts, 26 species)
Liliopsida - monocots (9 transcripts, 9 species)
Bryopsida - mosses (2 transcripts, 1 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Chordata
Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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