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HomoloGene:41022. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DMXL2,  H.sapiens
Dmx-like 2
NP_001167587.1
3037 aa
DMXL2,  P.troglodytes
Dmx-like 2
XP_510406.3
3037 aa
DMXL2,  C.lupus
Dmx-like 2
XP_005638465.1
3057 aa
DMXL2,  B.taurus
Dmx-like 2
XP_002691013.2
3001 aa
Dmxl2,  M.musculus
Dmx-like 2
NP_766359.2
3054 aa
Dmxl2,  R.norvegicus
Dmx-like 2
XP_006243160.1
3034 aa
DMXL2,  G.gallus
Dmx-like 2
XP_003641895.1
3046 aa
dmxl2,  X.tropicalis
Dmx-like 2
NP_001120527.2
3024 aa
LOC100536133,  D.rerio
dmX-like protein 2-like
XP_003200528.2
1547 aa
Rbcn-3A,  D.melanogaster
Rabconnectin-3A
NP_572302.2
3426 aa
AgaP_AGAP010490,  A.gambiae
AgaP_AGAP010490
XP_558026.3
3521 aa
rbc-1,  C.elegans
rbc-1
NP_001257246.1
3011 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Rabconnectin-3 is a functional regulator of mammalian Notch signaling.
Sethi N, et al. J Biol Chem 285, 34757-64 (2010).
Metabolic disruption in Drosophila bang-sensitive seizure mutants.
Fergestad T, et al. Genetics 173, 1357-64 (2006).
Chromosomal elements evolve at different rates in the Drosophila genome.
González J, et al. Genetics 161, 1137-54 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Rav1p_C (pfam12234)
  RAVE protein 1 C terminal.
COG2319 (COG2319)
  FOG: WD40 repeat [General function prediction only].
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Rav1p_C (pfam12234)
  RAVE protein 1 C terminal.
WD40 (cl02567)
  Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dmxl2 includes H.sapiens DMXL2 and R.norvegicus Dmxl2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (27 transcripts, 12 species)
Actinopterygii - bony fishes (20 transcripts, 8 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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