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HomoloGene:8516. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FOXP3,  H.sapiens
forkhead box P3
NP_054728.2
431 aa
FOXP3,  M.mulatta
forkhead box P3
NP_001028090.1
431 aa
FOXP3,  C.lupus
forkhead box P3
NP_001161933.1
430 aa
FOXP3,  B.taurus
forkhead box P3
NP_001039398.1
431 aa
Foxp3,  M.musculus
forkhead box P3
NP_473380.1
429 aa
Foxp3,  R.norvegicus
forkhead box P3
NP_001101720.1
429 aa
foxp3,  X.tropicalis
forkhead box P3
XP_002941017.2
439 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, type I, susceptibility to.
Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked.



Publications
Articles associated with genes and sequences of this homology group.

B cells are critical for autoimmune pathology in Scurfy mice.
Aschermann S, et al. Proc Natl Acad Sci U S A 110, 19042-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FH (cl00061)
  Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Foxp3 includes H.sapiens FOXP3 and R.norvegicus Foxp3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)

 

 

 

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