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HomoloGene:20083. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GLRA1,  H.sapiens
glycine receptor, alpha 1
NP_001139512.1
457 aa
GLRA1,  P.troglodytes
glycine receptor, alpha 1
XP_001169235.1
457 aa
GLRA1,  M.mulatta
glycine receptor, alpha 1
XP_002804635.1
457 aa
GLRA1,  C.lupus
glycine receptor, alpha 1
XP_003434572.1
457 aa
GLRA1,  B.taurus
glycine receptor, alpha 1
NP_776746.1
457 aa
Glra1,  M.musculus
glycine receptor, alpha 1 subunit
NP_065238.2
449 aa
Glra1,  R.norvegicus
glycine receptor, alpha 1
NP_037265.1
449 aa
GLRA1,  G.gallus
glycine receptor, alpha 1
XP_425210.3
458 aa
glra1,  X.tropicalis
glycine receptor, alpha 1
XP_004912784.1
458 aa
glra1,  D.rerio
glycine receptor, alpha 1
NP_571477.1
444 aa
GluClalpha,  D.melanogaster
GluClalpha
NP_001262740.1
457 aa
AgaP_AGAP001434,  A.gambiae
AgaP_AGAP001434
XP_003435829.1
456 aa
avr-14,  C.elegans
avr-14
NP_001020963.1
430 aa
glc-3,  C.elegans
glc-3
NP_504441.1
484 aa
avr-15,  C.elegans
avr-15
NP_001024076.1
657 aa
avr-15,  C.elegans
avr-15
NP_001024077.1
478 aa
glc-1,  C.elegans
glc-1
NP_507090.1
461 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperekplexia and spastic paraparesis.
Startle disease, autosomal recessive.
Startle disease/hyperekplexia, autosomal dominant.



Publications
Articles associated with genes and sequences of this homology group.

Glutamate is an inhibitory neurotransmitter in the Drosophila olfactory system.
Liu WW & Wilson RI. Proc Natl Acad Sci U S A 110, 10294-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Glra1 includes H.sapiens GLRA1 and R.norvegicus Glra1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Arthropoda
Insecta - insects (7 transcripts, 5 species)
Arachnida - arachnids (6 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (7 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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