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HomoloGene:3854. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GFI1,  H.sapiens
growth factor independent 1 transcription repressor
NP_005254.2
422 aa
GFI1,  P.troglodytes
growth factor independent 1 transcription repressor
XP_513562.3
244 aa
GFI1,  M.mulatta
growth factor independent 1 transcription repressor
XP_001099597.1
422 aa
GFI1,  C.lupus
growth factor independent 1 transcription repressor
NP_001012737.1
422 aa
GFI1,  B.taurus
growth factor independent 1 transcription repressor
NP_001178241.1
420 aa
Gfi1,  M.musculus
growth factor independent 1
NP_034408.1
423 aa
Gfi1,  R.norvegicus
growth factor independent 1 transcription repressor
NP_036698.1
423 aa
GFI1,  G.gallus
growth factor independent 1 transcription repressor
XP_426644.3
397 aa
gfi1,  X.tropicalis
growth factor independent 1 transcription repressor
XP_002933849.1
383 aa
gfi1ab,  D.rerio
growth factor independent 1ab
NP_958495.1
396 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Neutropenia, severe congenital.
Neutropenia, nonimmune chronic idiopathic, of adults.



Publications
Articles associated with genes and sequences of this homology group.

[Expression of growth-factor independence 1 in patients with leukemia and its significance].
Wang TT, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18, 834-7 (2010).
Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium.
Bjerknes M & Cheng H. Dev Biol 345, 49-63 (2010).
Solution structure of Gfi-1 zinc domain bound to consensus DNA.
Lee S, et al. J Mol Biol 397, 1055-66 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-H2C2_2 (pfam13465)
  Zinc-finger double domain.
zf-H2C2_2 (cl19539)
  Zinc-finger double domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gfi1 includes H.sapiens GFI1 and R.norvegicus Gfi1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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