Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:3904. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HINT1,  H.sapiens
histidine triad nucleotide binding protein 1
NP_005331.1
126 aa
HINT1,  P.troglodytes
histidine triad nucleotide binding protein 1
XP_003310848.1
126 aa
HINT1,  M.mulatta
histidine triad nucleotide binding protein 1
XP_001099859.1
126 aa
HINT1,  C.lupus
histidine triad nucleotide binding protein 1
XP_531895.2
126 aa
HINT1,  B.taurus
histidine triad nucleotide binding protein 1
NP_787006.1
126 aa
Hint1,  M.musculus
histidine triad nucleotide binding protein 1
NP_032274.1
126 aa
Hint1,  R.norvegicus
histidine triad nucleotide binding protein 1
NP_001103077.1
126 aa
HINT1,  G.gallus
histidine triad nucleotide binding protein 1
NP_990020.1
126 aa
hint1,  X.tropicalis
histidine triad nucleotide binding protein 1
NP_001016165.1
126 aa
hint1,  D.rerio
histidine triad nucleotide binding protein 1
NP_001005593.1
126 aa
CG2862,  D.melanogaster
CG2862
NP_608711.3
150 aa
AgaP_AGAP006353,  A.gambiae
AgaP_AGAP006353
XP_316373.4
127 aa
hint-1,  C.elegans
hint-1
NP_492056.1
130 aa
HIT3,  A.thaliana
HIT3
NP_567038.1
147 aa
Os03g0322500,  O.sativa
Os03g0322500
NP_001049967.1
129 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Kinetic mechanism of human histidine triad nucleotide binding protein 1.
Zhou X, et al. Biochemistry 52, 3588-600 (2013).
Acute behavioral effects of nicotine in male and female HINT1 knockout mice.
Jackson KJ, et al. Genes Brain Behav 11, 993-1000 (2012).
Differential expression of HINT1 in schizophrenia brain tissue.
Varadarajulu J, et al. Eur Arch Psychiatry Clin Neurosci 262, 167-72 (2012).
Increased anxiety-related behaviour in Hint1 knockout mice.
Varadarajulu J, et al. Behav Brain Res 220, 305-11 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HIT_like (cl00228)
  HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hint1 includes H.sapiens HINT1 and R.norvegicus Hint1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (28 transcripts, 17 species)
Actinopterygii - bony fishes (11 transcripts, 10 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Aves - birds (5 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (19 transcripts, 12 species)
Arachnida - arachnids (4 transcripts, 2 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (41 transcripts, 30 species)
Liliopsida - monocots (20 transcripts, 9 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

 

 

 

Support Center