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HomoloGene:19067. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CHD7,  H.sapiens
chromodomain helicase DNA binding protein 7
NP_060250.2
2997 aa
CHD7,  P.troglodytes
chromodomain helicase DNA binding protein 7
XP_519780.3
2997 aa
CHD7,  M.mulatta
chromodomain helicase DNA binding protein 7
XP_002805403.1
2990 aa
CHD7,  C.lupus
chromodomain helicase DNA binding protein 7
XP_544097.2
2995 aa
CHD7,  B.taurus
chromodomain helicase DNA binding protein 7
XP_002692716.2
2935 aa
Chd7,  M.musculus
chromodomain helicase DNA binding protein 7
NP_001264078.1
2986 aa
Chd7,  R.norvegicus
chromodomain helicase DNA binding protein 7
XP_003749947.1
2985 aa
CHD7,  G.gallus
chromodomain helicase DNA binding protein 7
NP_001071054.1
3011 aa
chd7,  X.tropicalis
chromodomain helicase DNA binding protein 7
XP_002936158.2
2969 aa
chd7,  D.rerio
chromodomain helicase DNA binding protein 7
XP_697956.4
3140 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
CHARGE syndrome.
Scoliosis, idiopathic 3.



Publications
Articles associated with genes and sequences of this homology group.

The cardiac phenotype in patients with a CHD7 mutation.
Corsten-Janssen N, et al. Circ Cardiovasc Genet 6, 248-54 (2013).
CHARGE syndrome: diagnosis and clinical management in the NICU.
Allen T. Adv Neonatal Care 12, 336-42; quiz 343-4 (2012).
Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders.
Bouazoune K & Kingston RE. Proc Natl Acad Sci U S A 109, 19238-43 (2012).
Mutation update on the CHD7 gene involved in CHARGE syndrome.
Janssen N, et al. Hum Mutat 33, 1149-60 (2012).
Ophthalmic features of CHARGE syndrome with CHD7 mutations.
Nishina S, et al. Am J Med Genet A 158A, 514-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BRK (pfam07533)
  BRK domain.
SNF2_N (pfam00176)
  SNF2 family N-terminal domain.
Med15 (pfam09606)
  ARC105 or Med15 subunit of Mediator complex non-fungal.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
SNF2_N (pfam00176)
  SNF2 family N-terminal domain.
HNF-1B_C (pfam04812)
  Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus.
Fork_head_N (pfam08430)
  Forkhead N-terminal region.
DAZAP2 (pfam11029)
  DAZ associated protein 2 (DAZAP2).
Neuro_bHLH (pfam12533)
  Neuronal helix-loop-helix transcription factor.
BRK (cl02688)
  BRK domain.
CHROMO (cl17459)
  Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence implicates the chromo domain in the binding activity of these proteins to methylated histone tails and maybe RNA. May occur as single instance, in a tandem arrangement or followd by a related "chromo shadow" domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chd7 includes H.sapiens CHD7 and R.norvegicus Chd7.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (37 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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