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HomoloGene:12892. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

OTOF,  H.sapiens
otoferlin
NP_919224.1
1997 aa
OTOF,  P.troglodytes
otoferlin
XP_003949828.1
1883 aa
OTOF,  M.mulatta
otoferlin
XP_002799220.1
2059 aa
OTOF,  C.lupus
otoferlin
XP_005630285.1
2012 aa
OTOF,  B.taurus
otoferlin
NP_001137579.1
1998 aa
Otof,  M.musculus
otoferlin
NP_114081.2
1997 aa
Otof,  R.norvegicus
otoferlin
NP_001263649.1
1998 aa
OTOF,  G.gallus
otoferlin
XP_420015.2
2010 aa
otof,  X.tropicalis
otoferlin
XP_004918245.1
1913 aa
otof,  D.rerio
otoferlin
NP_001025283.1
1992 aa
AgaP_AGAP000389,  A.gambiae
AgaP_AGAP000389
XP_310715.5
2099 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal recessive 9.



Publications
Articles associated with genes and sequences of this homology group.

Screening of OTOF mutations in Iran: a novel mutation and review.
Mahdieh N, et al. Int J Pediatr Otorhinolaryngol 76, 1610-5 (2012).
Identification of the hair cell soma-1 antigen, HCS-1, as otoferlin.
Goodyear RJ, et al. J Assoc Res Otolaryngol 11, 573-86 (2010).
OTOF-Related Deafness
Shearer AE, et al. (1993).
Mutations in the OTOF gene in Taiwanese patients with auditory neuropathy.
Chiu YH, et al. Audiol Neurootol 15, 364-74 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FerB (pfam08150)
  FerB (NUC096) domain.
FerI (pfam08151)
  FerI (NUC094) domain.
C2 (cl14603)
  C2 domain.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Otof includes H.sapiens OTOF and R.norvegicus Otof.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (10 transcripts, 5 species)
Mammalia - mammals (5 transcripts, 5 species)
Ascidiacea - tunicates (3 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (3 transcripts, 1 species)
Trematoda - flatworms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (4 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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