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HomoloGene:105965. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SHANK2,  H.sapiens
SH3 and multiple ankyrin repeat domains 2
NP_036441.2
1849 aa
SHANK2,  M.mulatta
SH3 and multiple ankyrin repeat domains 2
XP_001099714.2
1261 aa
SHANK2,  C.lupus
SH3 and multiple ankyrin repeat domains 2
XP_005631799.1
1914 aa
SHANK2,  B.taurus
SH3 and multiple ankyrin repeat domains 2
XP_002699471.1
1847 aa
Shank2,  M.musculus
SH3/ankyrin domain gene 2
NP_001106844.2
1472 aa
Shank2,  R.norvegicus
SH3 and multiple ankyrin repeat domains 2
NP_958738.1
1839 aa
SHANK2,  G.gallus
SH3 and multiple ankyrin repeat domains 2
XP_426415.4
1858 aa
shank2,  X.tropicalis
SH3 and multiple ankyrin repeat domains 2
NP_001096183.1
1460 aa
shank2,  D.rerio
SH3 and multiple ankyrin repeat domains 2
NP_001121819.1
1800 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Autism, susceptibility to, 17.



Publications
Articles associated with genes and sequences of this homology group.

The emerging role of SHANK genes in neuropsychiatric disorders.
Guilmatre A, et al. Dev Neurobiol 74, 113-22 (2014).
Expression of postsynaptic density proteins of the ProSAP/Shank family in the thymus.
Redecker P, et al. Histochem Cell Biol 126, 679-85 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Shank2 includes H.sapiens SHANK2 and R.norvegicus Shank2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 7 species)
Actinopterygii - bony fishes (7 transcripts, 5 species)
Amphibia - amphibians (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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