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HomoloGene:4104. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DLL1,  H.sapiens
delta-like 1 (Drosophila)
NP_005609.3
723 aa
DLL1,  P.troglodytes
delta-like 1 (Drosophila)
XP_520601.2
723 aa
DLL1,  C.lupus
delta-like 1 (Drosophila)
XP_005627852.1
689 aa
DLL1,  B.taurus
delta-like 1 (Drosophila)
XP_002690447.1
722 aa
Dll1,  M.musculus
delta-like 1 (Drosophila)
NP_031891.2
722 aa
Dll1,  R.norvegicus
delta-like 1 (Drosophila)
NP_114452.1
714 aa
DLL1,  G.gallus
delta-like 1 (Drosophila)
NP_990304.1
728 aa
dll1,  X.tropicalis
delta-like 1
NP_001093689.1
721 aa
dld,  D.rerio
deltaD
NP_571030.2
717 aa
Dl,  D.melanogaster
Delta
NP_001247193.1
833 aa
AgaP_AGAP010265,  A.gambiae
AgaP_AGAP010265
XP_319454.4
660 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
A haplo-insufficient member of the group of neurogenic genes originally described on the basis of its dominant phenotype. Several classes of alleles designated by Vassin and Campos-Ortega based on the phenotype of heterozygous adults: Amorphic and strong hypomorphic alleles display wing veins widened at their junctions with the margin to form δ-like structures; in addition, they show irregular thickening of vein 2 and wings frequently held in divergent attitude; fusion of ommatidia may give rise to disruptions in regular hexagonal array of eye facets; ocelli are slightly enlarged; additional bristles are present on head, thorax, and abdomen; homozygotes die as embryos. (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MNNL (pfam07657)
  N terminus of Notch ligand.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
MNNL (pfam07657)
  N terminus of Notch ligand.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
DSL (cl19567)
  Delta serrate ligand.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dll1 includes H.sapiens DLL1 and R.norvegicus Dll1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 9 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (6 transcripts, 2 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)

 

 

 

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