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HomoloGene:4479. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IRF6,  H.sapiens
interferon regulatory factor 6
NP_006138.1
467 aa
IRF6,  P.troglodytes
interferon regulatory factor 6
XP_514168.2
467 aa
IRF6,  M.mulatta
interferon regulatory factor 6
XP_001110321.1
467 aa
IRF6,  C.lupus
interferon regulatory factor 6
XP_005622392.1
462 aa
IRF6,  B.taurus
interferon regulatory factor 6
NP_001070402.1
467 aa
Irf6,  M.musculus
interferon regulatory factor 6
NP_058547.2
467 aa
Irf6,  R.norvegicus
interferon regulatory factor 6
NP_001102329.1
467 aa
IRF6,  G.gallus
interferon regulatory factor 6
XP_417990.4
470 aa
irf6,  X.tropicalis
interferon regulatory factor 6
NP_001025493.1
460 aa
irf6,  D.rerio
interferon regulatory factor 6
NP_956892.1
492 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
van der Woude syndrome.
Popliteal pterygium syndrome.
Orofacial cleft 6.



Publications
Articles associated with genes and sequences of this homology group.

IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population.
Brito LA, et al. Am J Med Genet A 158A, 2170-5 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IRF-3 (pfam10401)
  Interferon-regulatory factor 3.
IRF-3 (pfam10401)
  Interferon-regulatory factor 3.
IRF (cl00096)
  Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Irf6 includes H.sapiens IRF6 and R.norvegicus Irf6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amphibia - amphibians (6 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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