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HomoloGene:37259. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CLN3,  H.sapiens
ceroid-lipofuscinosis, neuronal 3
NP_001035897.1
438 aa
CLN3,  C.lupus
ceroid-lipofuscinosis, neuronal 3
NP_001013435.1
438 aa
CLN3,  B.taurus
ceroid-lipofuscinosis, neuronal 3
NP_001068642.2
438 aa
Cln3,  M.musculus
ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
NP_034037.3
438 aa
Cln3,  R.norvegicus
ceroid-lipofuscinosis, neuronal 3
NP_001006972.1
438 aa
cln3,  X.tropicalis
ceroid-lipofuscinosis, neuronal 3
XP_004919824.1
522 aa
cln3,  D.rerio
ceroid-lipofuscinosis, neuronal 3
NP_001007307.1
446 aa
cln3,  D.melanogaster
cln3
NP_649011.1
422 aa
AgaP_AGAP003934,  A.gambiae
AgaP_AGAP003934
XP_318386.5
448 aa
cln-3.2,  C.elegans
cln-3.2
NP_491556.1
435 aa
cln-3.1,  C.elegans
cln-3.1
NP_001256315.1
424 aa
cln-3.3,  C.elegans
cln-3.3
NP_505237.1
417 aa
YHC3,  S.cerevisiae
YHC3
NP_012476.1
408 aa
KLLA0F01551g,  K.lactis
KLLA0F01551g
XP_455150.1
387 aa
AGOS_AEL171C,  E.gossypii
AGOS_AEL171C
NP_984690.1
412 aa
btn1,  S.pombe
btn1
NP_593598.1
396 aa
MGG_06604,  M.oryzae
MGG_06604
XP_003716923.1
472 aa
NCU10272,  N.crassa
NCU10272
XP_001728107.1
464 aa
NCU08408,  N.crassa
NCU08408
XP_963280.2
464 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ceroid-lipofuscinosis, neuronal-3, juvenile.



Publications
Articles associated with genes and sequences of this homology group.

Osmoregulation of ceroid neuronal lipofuscinosis type 3 in the renal medulla.
Stein CS, et al. Am J Physiol Cell Physiol 298, C1388-400 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CLN3 (pfam02487)
  CLN3 protein.
CLN3 (pfam02487)
  CLN3 protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cln3 includes H.sapiens CLN3 and R.norvegicus Cln3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 8 species)

Nematoda
Chromadorea - nematodes (5 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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