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HomoloGene:1633. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ID3,  H.sapiens
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
NP_002158.3
119 aa
ID3,  P.troglodytes
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
XP_003949371.1
119 aa
ID3,  C.lupus
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
NP_001003025.1
119 aa
ID3,  B.taurus
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
NP_001014950.1
119 aa
Id3,  M.musculus
inhibitor of DNA binding 3
NP_032347.1
119 aa
Id3,  R.norvegicus
inhibitor of DNA binding 3
NP_037190.1
119 aa
ID3,  G.gallus
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
NP_989920.1
125 aa
id3,  X.tropicalis
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
NP_001016271.1
118 aa
id3,  D.rerio
inhibitor of DNA binding 3
NP_694499.1
116 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

ID3 mutations are recurrent events in double-hit B-cell lymphomas.
Gebauer N, et al. Anticancer Res 33, 4771-8 (2013).
Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice.
Lipinski MJ, et al. Arterioscler Thromb Vasc Biol 32, 2855-61 (2012).
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion.
Cutchins A, et al. Arterioscler Thromb Vasc Biol 32, 317-24 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Id3 includes H.sapiens ID3 and R.norvegicus Id3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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