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HomoloGene:395. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HNF4A,  H.sapiens
hepatocyte nuclear factor 4, alpha
NP_000448.3
474 aa
HNF4A,  P.troglodytes
hepatocyte nuclear factor 4, alpha
XP_514664.4
482 aa
HNF4A,  M.mulatta
hepatocyte nuclear factor 4, alpha
XP_001110097.2
462 aa
HNF4A,  C.lupus
hepatocyte nuclear factor 4, alpha
XP_852731.1
474 aa
HNF4A,  B.taurus
hepatocyte nuclear factor 4, alpha
NP_001015557.1
455 aa
Hnf4a,  M.musculus
hepatic nuclear factor 4, alpha
NP_032287.2
474 aa
Hnf4a,  R.norvegicus
hepatocyte nuclear factor 4, alpha
NP_071516.2
474 aa
HNF4A,  G.gallus
hepatocyte nuclear factor 4, alpha
NP_001026026.1
454 aa
hnf4a,  X.tropicalis
hepatocyte nuclear factor 4, alpha
XP_002933229.2
466 aa
hnf4a,  D.rerio
hepatocyte nuclear factor 4, alpha
NP_919349.1
454 aa
AgaP_AGAP002155,  A.gambiae
AgaP_AGAP002155
XP_308036.5
596 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
MODY, type I.
Diabetes mellitus, noninsulin-dependent.



Publications
Articles associated with genes and sequences of this homology group.

HNF4α as a marker for invasive mucinous adenocarcinoma of the lung.
Sugano M, et al. Am J Surg Pathol 37, 211-8 (2013).
[Zinc supplementation effects on alcoholic liver disease and the molecular mechanism].
Xiao M, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi 28, 84-8 (2012).
The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
Frochot V, et al. Am J Physiol Gastrointest Liver Physiol 302, G1253-63 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hnf4a includes H.sapiens HNF4A and R.norvegicus Hnf4a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 10 species)
Mammalia - mammals (11 transcripts, 9 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 4 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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