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HomoloGene:7221. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TARDBP,  H.sapiens
TAR DNA binding protein
NP_031401.1
414 aa
TARDBP,  P.troglodytes
TAR DNA binding protein
XP_514380.2
414 aa
TARDBP,  M.mulatta
TAR DNA binding protein
XP_001102660.1
414 aa
TARDBP,  C.lupus
TAR DNA binding protein
XP_005618063.1
607 aa
TARDBP,  B.taurus
TAR DNA binding protein
NP_001039950.2
414 aa
Tardbp,  M.musculus
TAR DNA binding protein
NP_663531.1
414 aa
TARDBP,  G.gallus
TAR DNA binding protein
NP_001026049.1
414 aa
tardbp,  X.tropicalis
TAR DNA binding protein
NP_989054.2
409 aa
tardbp,  D.rerio
TAR DNA binding protein
NP_958884.1
412 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amyotrophic lateral sclerosis 10.



Publications
Articles associated with genes and sequences of this homology group.

TDP-43 in ALS: stay on target…almost there.
Jovičić A & Gitler AD. Neuron 81, 463-5 (2014).
Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43.
Lukavsky PJ, et al. Nat Struct Mol Biol 20, 1443-9 (2013).
Altered astrocytic expression of TDP-43 does not influence motor neuron survival.
Haidet-Phillips AM, et al. Exp Neurol 250, 250-9 (2013).
TDP-43 pathology, cognitive decline, and dementia in old age.
Wilson RS, et al. JAMA Neurol 70, 1418-24 (2013).
Inhibition of TDP-43 aggregation by nucleic acid binding.
Huang YC, et al. PLoS One 8, e64002 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RRM_SF (cl17169)
  RNA recognition motif (RRM) superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tardbp includes H.sapiens TARDBP.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 14 species)
Actinopterygii - bony fishes (16 transcripts, 9 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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