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HomoloGene:4084. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MUSK,  H.sapiens
muscle, skeletal, receptor tyrosine kinase
NP_005583.1
869 aa
MUSK,  P.troglodytes
muscle, skeletal, receptor tyrosine kinase
XP_001146498.1
869 aa
MUSK,  M.mulatta
muscle, skeletal, receptor tyrosine kinase
XP_001106626.1
869 aa
MUSK,  C.lupus
muscle, skeletal, receptor tyrosine kinase
XP_538784.4
912 aa
MUSK,  B.taurus
muscle, skeletal, receptor tyrosine kinase
NP_001179281.1
869 aa
Musk,  M.musculus
muscle, skeletal, receptor tyrosine kinase
NP_001032204.2
893 aa
Musk,  R.norvegicus
muscle, skeletal, receptor tyrosine kinase
NP_112323.1
868 aa
MUSK,  G.gallus
muscle, skeletal, receptor tyrosine kinase
NP_989439.1
947 aa
musk,  X.tropicalis
muscle, skeletal, receptor tyrosine kinase
XP_002940313.2
865 aa
musk,  D.rerio
muscle, skeletal, receptor tyrosine kinase
NP_001004503.1
941 aa
Nrk,  D.melanogaster
Neurospecific receptor kinase
NP_477255.1
724 aa
AgaP_AGAP006988,  A.gambiae
AgaP_AGAP006988
XP_308783.2
699 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.
Hubbard SR & Gnanasambandan K. Biochim Biophys Acta 1834, 2166-9 (2013).
Increasing MuSK activity delays denervation and improves motor function in ALS mice.
Pérez-García MJ & Burden SJ. Cell Rep 2, 497-502 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
I-set (pfam07679)
  Immunoglobulin I-set domain.
CRD_FZ (cl02447)
  CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.
I-set (pfam07679)
  Immunoglobulin I-set domain.
KR (cl00100)
  Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
CRD_FZ (cl02447)
  CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Musk includes H.sapiens MUSK and R.norvegicus Musk.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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