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HomoloGene:3242. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DFNA5,  H.sapiens
deafness, autosomal dominant 5
NP_004394.1
496 aa
DFNA5,  P.troglodytes
deafness, autosomal dominant 5
XP_001159685.2
496 aa
DFNA5,  M.mulatta
deafness, autosomal dominant 5
XP_001096330.1
495 aa
DFNA5,  C.lupus
deafness, autosomal dominant 5
XP_853956.2
495 aa
DFNA5,  B.taurus
deafness, autosomal dominant 5
NP_001180041.1
496 aa
Dfna5,  M.musculus
deafness, autosomal dominant 5 (human)
NP_061239.1
512 aa
Dfna5,  R.norvegicus
deafness, autosomal dominant 5 (human)
NP_001178678.1
507 aa
DFNA5,  G.gallus
deafness, autosomal dominant 5
NP_001006361.1
505 aa
dfna5,  X.tropicalis
deafness, autosomal dominant 5
XP_002933445.2
514 aa
dfna5,  D.rerio
deafness, autosomal dominant 5
NP_001001947.1
472 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal dominant 5.



Publications
Articles associated with genes and sequences of this homology group.

Methylation of the DFNA5 gene is frequently detected in colorectal cancer.
Yokomizo K, et al. Anticancer Res 32, 1319-22 (2012).
[Characteristics of audiology and clinical genetics of a Chinese family with the DFNA5 genetic hearing loss].
Jin Z, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 25, 395-8 (2011).
Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer.
Kim MS, et al. Biochem Biophys Res Commun 370, 38-43 (2008).
A novel DFNA5 mutation does not cause hearing loss in an Iranian family.
Van Laer L, et al. J Hum Genet 52, 549-52 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Gasdermin (pfam04598)
  Gasdermin family.
Gasdermin (pfam04598)
  Gasdermin family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dfna5 includes H.sapiens DFNA5 and R.norvegicus Dfna5h.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 6 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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