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HomoloGene:55465. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CFTR,  H.sapiens
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_000483.3
1480 aa
CFTR,  P.troglodytes
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_001073386.1
1480 aa
CFTR,  M.mulatta
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_001028110.1
1481 aa
CFTR,  C.lupus
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_001007144.1
1483 aa
CFTR,  B.taurus
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_776443.1
1481 aa
Cftr,  M.musculus
cystic fibrosis transmembrane conductance regulator
NP_066388.1
1476 aa
Cftr,  R.norvegicus
cystic fibrosis transmembrane conductance regulator
NP_113694.1
1476 aa
CFTR,  G.gallus
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_001099136.1
1484 aa
cftr,  X.tropicalis
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
XP_002935002.2
1482 aa
cftr,  D.rerio
cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
NP_001038348.1
1485 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cystic fibrosis.
Congenital bilateral absence of vas deferens.
Hypertrypsinemia, neonatal.
Pancreatitis, idiopathic.
Sweat chloride elevation without CF.



Publications
Articles associated with genes and sequences of this homology group.

Cigarette smoke and CFTR: implications in the pathogenesis of COPD.
Rab A, et al. Am J Physiol Lung Cell Mol Physiol 305, L530-41 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ABC_membrane (pfam00664)
  ABC transporter transmembrane region.
CFTR_R (pfam14396)
  Cystic fibrosis TM conductance regulator (CFTR), regulator domain.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
ABC_membrane (pfam00664)
  ABC transporter transmembrane region.
CFTR_R (pfam14396)
  Cystic fibrosis TM conductance regulator (CFTR), regulator domain.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cftr includes H.sapiens CFTR and R.norvegicus Cftr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 13 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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