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HomoloGene:56754. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ERAP1,  H.sapiens
endoplasmic reticulum aminopeptidase 1
NP_057526.3
948 aa
ERAP1,  P.troglodytes
endoplasmic reticulum aminopeptidase 1
XP_003310814.1
948 aa
ERAP1,  M.mulatta
endoplasmic reticulum aminopeptidase 1
XP_001094790.1
896 aa
ERAP1,  C.lupus
endoplasmic reticulum aminopeptidase 1
XP_005618143.1
942 aa
ERAP1,  B.taurus
endoplasmic reticulum aminopeptidase 1
NP_001095473.1
942 aa
Erap1,  M.musculus
endoplasmic reticulum aminopeptidase 1
NP_109636.1
930 aa
Erap1,  R.norvegicus
endoplasmic reticulum aminopeptidase 1
NP_110463.1
884 aa
ERAP1,  G.gallus
endoplasmic reticulum aminopeptidase 1
XP_001232418.2
929 aa
erap1,  X.tropicalis
endoplasmic reticulum aminopeptidase 1
XP_002933475.2
932 aa
zgc:56194,  D.rerio
zgc:56194
NP_956500.2
963 aa
si:dkey-24n17.6,  D.rerio
si:dkey-24n17.6
XP_005155589.1
954 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role.
Alvarez-Navarro C & López de Castro JA. Curr Opin Rheumatol 25, 419-25 (2013).
ERAP1 and ankylosing spondylitis.
Keidel S, et al. Curr Opin Immunol 25, 97-102 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3358 (pfam11838)
  Domain of unknown function (DUF3358).
ERAP1_C (pfam11838)
  ERAP1-like C-terminal domain.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Erap1 includes H.sapiens ERAP1 and R.norvegicus Erap1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (10 transcripts, 5 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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