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HomoloGene:5275. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MME,  H.sapiens
membrane metallo-endopeptidase
NP_009220.2
750 aa
MME,  P.troglodytes
membrane metallo-endopeptidase
XP_001148532.1
750 aa
MME,  M.mulatta
membrane metallo-endopeptidase
XP_001105907.1
750 aa
MME,  C.lupus
membrane metallo-endopeptidase
XP_005634647.1
749 aa
MME,  B.taurus
membrane metallo-endopeptidase
NP_001179813.1
750 aa
Mme,  M.musculus
membrane metallo endopeptidase
NP_032630.2
750 aa
Mme,  R.norvegicus
membrane metallo-endopeptidase
NP_036740.1
750 aa
MME,  G.gallus
membrane metallo-endopeptidase
NP_001004412.1
750 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Membranous glomerulonephritis, antenatal.
Neutral endopeptidase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

The role of neprilysin in regulating the hair cycle.
Morisaki N, et al. PLoS One 8, e55947 (2013).
Negative regulation of NEP expression by hypoxia.
Mitra R, et al. Prostate 73, 706-14 (2013).
Anti-CD10 (56C6) expression in soft tissue sarcomas.
Deniz K, et al. Pathol Res Pract 208, 281-5 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mme includes H.sapiens MME and R.norvegicus Mme.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 14 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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