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HomoloGene:10304. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PTF1A,  H.sapiens
pancreas specific transcription factor, 1a
NP_835455.1
328 aa
PTF1A,  P.troglodytes
pancreas specific transcription factor, 1a
XP_001146416.2
142 aa
PTF1A,  C.lupus
pancreas specific transcription factor, 1a
XP_850386.2
328 aa
PTF1A,  B.taurus
pancreas specific transcription factor, 1a
XP_002707767.1
326 aa
Ptf1a,  M.musculus
pancreas specific transcription factor, 1a
NP_061279.2
324 aa
Ptf1a,  R.norvegicus
pancreas specific transcription factor, 1a
NP_446416.1
326 aa
ptf1a,  X.tropicalis
pancreas specific transcription factor, 1a
XP_002933181.2
320 aa
ptf1a,  D.rerio
pancreas specific transcription factor, 1a
NP_997524.1
265 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, permanent neonatal, with cerebellar agenesis.



Publications
Articles associated with genes and sequences of this homology group.

Suppression of Ptf1a activity induces acinar-to-endocrine conversion.
Hesselson D, et al. Curr Biol 21, 712-7 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptf1a includes H.sapiens PTF1A and R.norvegicus Ptf1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 5 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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