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HomoloGene:4360. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SIX1,  H.sapiens
SIX homeobox 1
NP_005973.1
284 aa
SIX1,  P.troglodytes
SIX homeobox 1
XP_509988.2
284 aa
SIX1,  M.mulatta
SIX homeobox 1
XP_001096585.1
284 aa
SIX1,  C.lupus
SIX homeobox 1
XP_547841.3
284 aa
SIX1,  B.taurus
SIX homeobox 1
XP_002691065.3
284 aa
Six1,  M.musculus
sine oculis-related homeobox 1
NP_033215.2
284 aa
Six1,  R.norvegicus
SIX homeobox 1
NP_446211.1
284 aa
SIX1,  G.gallus
SIX homeobox 1
NP_001038150.1
282 aa
six1,  X.tropicalis
SIX homeobox 1
NP_001093693.1
284 aa
six1b,  D.rerio
sine oculis homeobox homolog 1b
NP_996978.1
284 aa
so,  D.melanogaster
sine oculis
NP_476733.1
416 aa
AgaP_AGAP011695,  A.gambiae
AgaP_AGAP011695
XP_320814.4
366 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal dominant 23.
Brachiootic syndrome 3.



Publications
Articles associated with genes and sequences of this homology group.

Six1 mediates resistance to paclitaxel in breast cancer cells.
Li Z, et al. Biochem Biophys Res Commun 441, 538-43 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Six1 includes H.sapiens SIX1 and R.norvegicus Six1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 9 species)
Mammalia - mammals (10 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Hyperoartia - vertebrates (3 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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