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HomoloGene:37748. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TIMP4,  H.sapiens
TIMP metallopeptidase inhibitor 4
NP_003247.1
224 aa
TIMP4,  P.troglodytes
TIMP metallopeptidase inhibitor 4
XP_516284.1
224 aa
TIMP4,  M.mulatta
TIMP metallopeptidase inhibitor 4
XP_002802742.1
224 aa
TIMP4,  C.lupus
TIMP metallopeptidase inhibitor 4
XP_003432791.1
224 aa
TIMP4,  B.taurus
TIMP metallopeptidase inhibitor 4
NP_001039336.1
224 aa
Timp4,  M.musculus
tissue inhibitor of metalloproteinase 4
NP_542370.3
224 aa
Timp4,  R.norvegicus
tissue inhibitor of metalloproteinase 4
NP_001102863.1
224 aa
TIMP4,  G.gallus
TIMP metallopeptidase inhibitor 4
XP_001232059.1
221 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Hypoxia inhibits cardiomyocyte proliferation in fetal rat hearts via upregulating TIMP-4.
Tong W, et al. Am J Physiol Regul Integr Comp Physiol 304, R613-20 (2013).
[Changing trends of the expression of TIMP-4 in mouse ovary during pregnant and postpartum period].
Bu SM, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi 24, 248-52 (2008).
Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4.
Donnini S, et al. FEBS Lett 582, 1135-40 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NTR_like (cl02512)
  NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Timp4 includes H.sapiens TIMP4 and R.norvegicus Timp4_mapped.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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