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HomoloGene:12326. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ARAP1,  H.sapiens
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
NP_001035207.1
1450 aa
ARAP1,  P.troglodytes
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
XP_508625.3
1473 aa
ARAP1,  M.mulatta
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
XP_001114962.1
1449 aa
ARAP1,  C.lupus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
XP_005633606.1
1446 aa
ARAP1,  B.taurus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
XP_002693483.1
1455 aa
Arap1,  M.musculus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
NP_001035200.1
1441 aa
Arap1,  R.norvegicus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
XP_006229959.1
1454 aa
LOC100332526,  D.rerio
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like
XP_002667258.3
1176 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

ARAP1 regulates endocytosis of EGFR.
Yoon HY, et al. Traffic 9, 2236-52 (2008).
ARAP1 regulates EGF receptor trafficking and signalling.
Daniele T, et al. Traffic 9, 2221-35 (2008).
ARAP1: a point of convergence for Arf and Rho signaling.
Miura K, et al. Mol Cell 9, 109-19 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RA (pfam00788)
  Ras association (RalGDS/AF-6) domain.
ArfGap (pfam01412)
  Putative GTPase activating protein for Arf.
UBQ (cl00155)
  Ubiquitin-like proteins.
ArfGap (cl02464)
  Putative GTPase activating protein for Arf.
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
PH-like (cl17171)
  Pleckstrin homology-like domain.
UBQ (cl00155)
  Ubiquitin-like proteins.
ArfGap (cl02464)
  Putative GTPase activating protein for Arf.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arap1 includes H.sapiens ARAP1 and R.norvegicus Centd2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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