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HomoloGene:2336. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SORL1,  H.sapiens
sortilin-related receptor, L(DLR class) A repeats containing
NP_003096.1
2214 aa
SORL1,  P.troglodytes
sortilin-related receptor, L(DLR class) A repeats containing
XP_003313440.1
2212 aa
SORL1,  M.mulatta
sortilin-related receptor, L(DLR class) A repeats containing
XP_001102178.2
2086 aa
SORL1,  C.lupus
sortilin-related receptor, L(DLR class) A repeats containing
XP_536545.2
2204 aa
SORL1,  B.taurus
sortilin-related receptor, L(DLR class) A repeats containing
NP_001179686.1
2211 aa
Sorl1,  M.musculus
sortilin-related receptor, LDLR class A repeats-containing
NP_035566.2
2215 aa
Sorl1,  R.norvegicus
sortilin-related receptor, LDLR class A repeats-containing
NP_445971.1
2215 aa
SORL1,  G.gallus
sortilin-related receptor, L(DLR class) A repeats containing
XP_001232946.3
2205 aa
sorl1,  X.tropicalis
sortilin-related receptor, L(DLR class) A repeats containing
XP_002941683.2
2193 aa
sorl1,  D.rerio
sortilin-related receptor, L(DLR class) A repeats containing
XP_005157607.1
2213 aa
AgaP_AGAP010896,  A.gambiae
AgaP_AGAP010896
XP_309795.4
1348 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alzheimer disease, pathogenesis, association with.



Publications
Articles associated with genes and sequences of this homology group.

Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease.
Willnow TE & Andersen OM. J Cell Sci 126, 2751-60 (2013).
SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer’s disease.
Guo LH, et al. Eur Arch Psychiatry Clin Neurosci 262, 529-34 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ldl_recept_b (cl10508)
  Low-density lipoprotein receptor repeat class B.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
VPS10 (smart00602)
  VPS10 domain.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sorl1 includes H.sapiens SORL1 and R.norvegicus Sorl1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 13 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)

 

 

 

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